My 12 year old belgian shepard has had a recurring bladder infection for at least 2 years. I’m in Chicago and my vet has tried a variety of antibiotics during this time, including cephalexin, amoxicillin, SMT, enrofloxacin, cipro, and gentamicin. A recent urine culture indicated that a strain of E. coli that seems to be at the root of this infection is resistant to 18 out of 21 antibiotics tested for sensitivity. The three that were indicated as being possible options were macrodantin, amikacin, and imipenem. Macrodantin was administered first and was discovered to be ineffective after a follow-up urinalysis. 10 amikacin injections were given next, and were found to be effective, but did not clear the infection completely. I’ve heard of bacteria being able to invade transitional epithelial cells and survive antibiotic administration and am wondering if this is the case here. The paper I’ve attached details that situation. I have two questions:
1) Would it be possible to administer antibiotics through injection to the areas where the bacteria might be “hiding”?
2)Are there any recommendations that you could make to my vet regarding this case?
Thanks in advance.
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